EFFECT OF AQUEOUS EXTRACT OF Ipomoea staphylina ON INDIAN EARTHWORM

Objective: Aqueous extract from the leaves of Ipomoea staphylina was investigated for its anthelmintic activity against Perionyx excavatus. Methods: Three concentrations (25, 50, 100 mg/ml) of extract were studied in activity, which involved the determination of time of paralysis and time of death of the worms. Piperazine citrate was included as standard reference and normal saline as control. Results: The extract exhibited no anthelmintic activity at all three concentrations. Conclusion: Further study is required on the different solvent extract to evaluate if there is any anthelmintic activity.Keywords: Ipomoea staphylina, anthelmintic, Perionyx excavatus and Piperazine citrate

Runtime asynchronous fault tolerance via speculation

Transient faults are emerging as a critical reliability concern in modern microprocessors. Redundant hardware solutions are commonly deployed to detect transient faults, but they are less flexible and cost-effective than software solutions. However, software solutions are rendered impractical because of high performance overheads. To address this problem, this paper presents Runtime Asynchronous Fault Tolerance via Speculation (RAFT), the fastest transient fault detection technique known to date. Serving as a layer between the application and the underlying platform, RAFT automatically generates two symmetric program instances from a program binary. It detects transient faults in a non-invasive way and exploits high-confidence value speculation to achieve low runtime overhead. Evaluation on a commodity multicore system demonstrates that RAFT delivers a geomean performance overhead of 2.83% on a set of 30 SPEC CPU benchmarks and STAMP benchmarks. Compared with existing transient fault detection techniques, RAFT exhibits the best performance and fault coverage, without requiring any change to the hardware or the software applications

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.

The Global Burden of Diseases, Injuries and Risk Factors 2017 includes a comprehensive assessment of incidence, prevalence, and years lived with disability (YLDs) for 354 causes in 195 countries and territories from 1990 to 2017. Previous GBD studies have shown how the decline of mortality rates from 1990 to 2016 has led to an increase in life expectancy, an ageing global population, and an expansion of the non-fatal burden of disease and injury. These studies have also shown how a substantial portion of the world's population experiences non-fatal health loss with considerable heterogeneity among different causes, locations, ages, and sexes. Ongoing objectives of the GBD study include increasing the level of estimation detail, improving analytical strategies, and increasing the amount of high-quality data. METHODS: We estimated incidence and prevalence for 354 diseases and injuries and 3484 sequelae. We used an updated and extensive body of literature studies, survey data, surveillance data, inpatient admission records, outpatient visit records, and health insurance claims, and additionally used results from cause of death models to inform estimates using a total of 68 781 data sources. Newly available clinical data from India, Iran, Japan, Jordan, Nepal, China, Brazil, Norway, and Italy were incorporated, as well as updated claims data from the USA and new claims data from Taiwan (province of China) and Singapore. We used DisMod-MR 2.1, a Bayesian meta-regression tool, as the main method of estimation, ensuring consistency between rates of incidence, prevalence, remission, and cause of death for each condition. YLDs were estimated as the product of a prevalence estimate and a disability weight for health states of each mutually exclusive sequela, adjusted for comorbidity. We updated the Socio-demographic Index (SDI), a summary development indicator of income per capita, years of schooling, and total fertility rate. Additionally, we calculated differences between male and female YLDs to identify divergent trends across sexes. GBD 2017 complies with the Guidelines for Accurate and Transparent Health Estimates Reporting

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) includes a comprehensive assessment of incidence, prevalence, and years lived with disability (YLDs) for 354 causes in 195 countries and territories from 1990 to 2017. Previous GBD studies have shown how the decline of mortality rates from 1990 to 2016 has led to an increase in life expectancy, an ageing global population, and an expansion of the non-fatal burden of disease and injury. These studies have also shown how a substantial portion of the world's population experiences non-fatal health loss with considerable heterogeneity among different causes, locations, ages, and sexes. Ongoing objectives of the GBD study include increasing the level of estimation detail, improving analytical strategies, and increasing the amount of high-quality data.; We estimated incidence and prevalence for 354 diseases and injuries and 3484 sequelae. We used an updated and extensive body of literature studies, survey data, surveillance data, inpatient admission records, outpatient visit records, and health insurance claims, and additionally used results from cause of death models to inform estimates using a total of 68 781 data sources. Newly available clinical data from India, Iran, Japan, Jordan, Nepal, China, Brazil, Norway, and Italy were incorporated, as well as updated claims data from the USA and new claims data from Taiwan (province of China) and Singapore. We used DisMod-MR 2.1, a Bayesian meta-regression tool, as the main method of estimation, ensuring consistency between rates of incidence, prevalence, remission, and cause of death for each condition. YLDs were estimated as the product of a prevalence estimate and a disability weight for health states of each mutually exclusive sequela, adjusted for comorbidity. We updated the Socio-demographic Index (SDI), a summary development indicator of income per capita, years of schooling, and total fertility rate. Additionally, we calculated differences between male and female YLDs to identify divergent trends across sexes. GBD 2017 complies with the Guidelines for Accurate and Transparent Health Estimates Reporting. Globally, for females, the causes with the greatest age-standardised prevalence were oral disorders, headache disorders, and haemoglobinopathies and haemolytic anaemias in both 1990 and 2017. For males, the causes with the greatest age-standardised prevalence were oral disorders, headache disorders, and tuberculosis including latent tuberculosis infection in both 1990 and 2017. In terms of YLDs, low back pain, headache disorders, and dietary iron deficiency were the leading Level 3 causes of YLD counts in 1990, whereas low back pain, headache disorders, and depressive disorders were the leading causes in 2017 for both sexes combined. All-cause age-standardised YLD rates decreased by 3·9% (95% uncertainty interval [UI] 3·1-4·6) from 1990 to 2017; however, the all-age YLD rate increased by 7·2% (6·0-8·4) while the total sum of global YLDs increased from 562 million (421-723) to 853 million (642-1100). The increases for males and females were similar, with increases in all-age YLD rates of 7·9% (6·6-9·2) for males and 6·5% (5·4-7·7) for females. We found significant differences between males and females in terms of age-standardised prevalence estimates for multiple causes. The causes with the greatest relative differences between sexes in 2017 included substance use disorders (3018 cases [95% UI 2782-3252] per 100 000 in males vs s1400 [1279-1524] per 100 000 in females), transport injuries (3322 [3082-3583] vs 2336 [2154-2535]), and self-harm and interpersonal violence (3265 [2943-3630] vs 5643 [5057-6302]). Global all-cause age-standardised YLD rates have improved only slightly over a period spanning nearly three decades. However, the magnitude of the non-fatal disease burden has expanded globally, with increasing numbers of people who have a wide spectrum of conditions. A subset of conditions has remained globally pervasive since 1990, whereas other conditions have displayed more dynamic trends, with different ages, sexes, and geographies across the globe experiencing varying burdens and trends of health loss. This study emphasises how global improvements in premature mortality for select conditions have led to older populations with complex and potentially expensive diseases, yet also highlights global achievements in certain domains of disease and injury

TrustGuard: A Containment Architecture with Verified Output

Computers today are so complex and opaque that a user cannot know everything occurring within the system. Most efforts toward computer security have focused on securing software. However, software security techniques implicitly assume correct execution by the underlying system, including the hardware. Securing these systems has been challenging due to their complexity and the proportionate attack surface they present during their design, manufacturing, deployment, and operation. Ultimately, the user’s trust in the system depends on claims made by each party supplying the system’s components. This dissertation presents the Containment Architecture with Verified Output (CAVO) model in recognition of the reality that existing tools and techniques are insufficient to secure complex hardware components in modern computing systems. Rather than attempt to secure each complex hardware component individually, CAVO establishes trust in hardware using a single, simple, separately manufactured component, called the Sentry. The Sentry bridges a physical gap between the untrusted system and its external interfaces and contains the effects of malicious behavior by untrusted system components before the external manifestation of any such effects. Thus, only the Sentry and the physical gap must be secured in order to assure users of the containment of malicious behavior. The simplicity and pluggability of CAVO’s Sentry enable suppliers and consumers to take additional measures to secure it, including formal verification, supervised manufacture, and supply chain diversification. This dissertation also presents TrustGuard—the first prototype CAVO design—to demonstrate the feasibility of the CAVO model. TrustGuard achieves containment by only allowing the communication of correctly executed results of signed software. The Sentry in TrustGuard leverages execution information obtained from the untrusted processor to enable efficient checking of the untrusted system’s work, even when the Sentry itself is simpler and much slower than the untrusted processor. Simulations show that TrustGuard can guarantee containment of malicious hardware components with a geomean of 8.5% decline in the processor’s performance, even when the Sentry operates at half the clock frequency of the complex, untrusted processor

Nematic-like band splitting and crystal field splitting in newly discovered hybrid 12442 iron-based superconductors

We present theoretical results of crystal field splitting and nematic-like band splitting based on density functional theory first principles electronic structure and Wannier fitted tight binding calculations on the newly discovered quasi two-dimensional $${\mathrm{ACa_2Fe_4As_4F_2}}$$ (where A = K, Rb, Cs) i.e., 12442 iron-based superconductors. The orbital selective anisotropy of band structures as well as Fermi surfaces are discussed through electronic structure calculations. The degeneracy of $$d_{xz}$$ and $$d_{yz}$$ orbitals are lifted in 12442 compounds due to the reduction of local symmetry $$D_{2d}$$ to $$C_{2v}$$ of Fe-site. This degeneracy lifting of $$d_{xz}$$ and $$d_{yz}$$ cause band reconstruction which in turn induce emergence of nematic-like splitting of some bands in these compounds. This splitting is maximum at the electron bands near the Brillouin zone corner. The details of band reconstruction and band splittings are explored using relativistic pseudopotential including spin orbit coupling. To verify the degeneracy lifting of $$d_{xz/yz}$$ level in 12442 compounds, crystal field splitting is calculated with tight binding fitting using maximally localized Wannier functions. In contrary to its parent 1111 and 122 compounds, the degeneracy lifting of $$d_{xz/yz}$$ may be responsible for intrinsic band splitting in tetragonal phase of these compounds